Central to the enabling of computational modelling is a comprehensive Knowledge Commons: the freely available resource of all knowledge from the Life Sciences that can be used for pathway assembly and computer simulations. A substantial part of this concerns the Gene Regulation Knowledge Commons targeted by GRECO: the Gene Regulation Consortium.

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A pdf of the project description can be downloaded here

Research on the cell's function in normal and diseased states has produced large amounts of knowledge. Modelling the behaviour of these cells and predicting how they will respond to changes in the environment and to drugs in particular, now requires the use of computational tools.

This new field of “Systems Medicine”, as many predict, will enable us to use digital simulations to select the best fitted treatment for individual patients, and enable the development of "personalised medicine".

Systems Medicine requires cooperation of scientists from many different backgrounds, who together develop and integrate various technologies and approaches. Our goal is to use a knowledge-based approach and build integrated models of genes, proteins and other cellular components. Combined with the relational network that links these components, this produces computer models that can predict the cell’s behaviour and how they will respond to particular drugs and drug combinations. Further development of this approach may result in a software platform that could support doctors in the hospital to offer tailor-made therapy to patients.


For more information on the project see 'About'